Question
What is Corey House Synthesis?
Answer
The Corey-House synthesis is a carbon-carbon bond forming reaction used in organic chemistry for the synthesis of alkenes from alkyl halides. The reaction involves the reaction of an alkyl halide with a lithium dialkylcuprate reagent in the presence of a base to form a new carbon-carbon bond. The general equation for the Corey-House synthesis is: R-X + LiR2Cu (R = alkyl group) + base → R-R + LiX + CuI where X represents a halogen atom (usually chlorine or bromine).Subscribe to our youtube channel!
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