Question

What is Corey-House-Posner-Whitesides Reaction?

Answer

Corey-House-Posner-Whitesides reaction is a carbon-carbon bond forming reaction used in organic chemistry for the synthesis of alkenes from alkyl halides. The reaction involves the reaction of an alkyl halide with a lithium dialkylcuprate reagent in the presence of a base to form a new carbon-carbon bond. The general equation for the Corey-House synthesis is: R-X + LiR2Cu (R = alkyl group) + base → R-R + LiX + CuI where X represents a halogen atom (usually chlorine or bromine).